Department of Nutrition and Food Hygiene
Wang Suqing (Professor)
Date:2015-12-30  Clicks:

 

Suqing Wang, M.D., Ph.D.

Professor in Department of Preventive Medicine

Deputy director in Experimental Teaching Center for Preventive Medicine

School of Health Sciences

Wuhan University

Wuhan, China, 430071

Cell: 17786397869

Office Tel: 027-68759972 

Email: swang2099@whu.edu.cn

 

Education

Huazhong University of Science Technology, School of medicine, PhD.

Huazhong University of Science Technology, School of medicine, MS

Henan Medical University, preventive medicine, BS

Academic Training

University of Wisconsin, School of Medicine and Public Health, Visiting Scholar

University of Wisconsin, School of Medicine and Public Health, Research Associate

University of Alabama, Department of Medicine, Postdoc fellow

Faculty Academic Appointments

1995/07-1999/09 Wuhan Iron and Steel Cooperation, Institute of industrial Health, Research Associate

2008/01 -       Wuhan University, School of Health Sciences (previous School of Public Health), Professor

 

Membership

Council member of Hubei Society of Nutrition(2012-present)

Member of Chinese Society of Nutrition (2008-present)

Member of Reviewing Expertise Group of Hubei Food Safety Enterprise Standard (2008-present)

 

Teaching Courses

2008-present     Nutrition and Food Hygiene        Undergraduate Course

                    

2009-present     Nutrition                       Undergraduate Course

                           Health and Hygiene             Undergraduate Course

                           English for Academic Purpose     Undergraduate Course          

2010-present     Community Medicine            Undergraduate Course

2013-present     Lab Safety and Good Practice      Graduate Course

2014-present     Introduction to Public Health      Undergraduate Course

2015-present     Preventive Medicine             Undergraduate Course

                          Lab Safety and Good Practice     Undergraduate Course

Supervisor Trainees

2016         Zhuanhong Yang             Graduate student

                Nawsherwan                Ph.D.

                Bakht Ramin Shah           Postdoc. Fellow

2015         Wenjing Mao               Graduate student

                Zhaoye Wu                 Graduate student

2014         Tingting Huang              Graduate student

                Jingyi Wang                 Graduate student

                Ya Chen                    Ph.D.

2013         Lu Li                      Graduate student

                Jin Yang                    Graduate student

                Xiaocong Liu                Ph.D.

2012         Yumeng Tang                Graduate student

                Qian Liao                   Graduate student

                Jing Feng                   Graduate student

 

Research Interests

1. Cyp1b1 in diet associated obesity and cognition decline. Our Lab is focused on the biochemical and molecular mechanisms that link Cyp1b1 with inflammation, obesity, insulin resistance and cognitive function. Our primary project investigates inflammation and its relationship to high fat-diet induced obesity with an emphasis on the role of cyp1b1 in macrophages phenotype switch (macrophage in fat, blood and brain tissue) in the regulation of energy homeostasis. In particular, we are determining whether type II macrophage provide a repair response to diet induced damage to neurons and whether cyp1b1 knockout interventions targeted at macrophage may influence the course of obesity and cognition decline. A second focus is to examine the role of inflammatory signaling in neurons and microglia in obesity associated with insulin resistance and cognitive impairment.

 

2. Klotho in preeclampsia. Klotho, as an aging suppressor gene, also expressed in the human placenta, but its function during pregnancy is unknown. Klotho is critical for vascular function, and has anti-inflammatory properties. Our group is focus on the role of klotho in maternal plasma and placenta during pregnancy and whether dietary and physical activity interventions target at klotho expression could improve pregnancy outcome in patients with preeclampsia.

 

Research Projects

Project Number: 30972463 (complete)

Agency: National Natural Science Foundation of China

Project Title: Role of Cyp1b1 in mice obesity and insulin resistance induced by high fat diet.

My role: PI

 

Project Number: 81172664 (complete)

Agency: National Natural Science Foundation of China

Project Title: Brain microvascular function regulated by Cyp1b1 in cognitive impairment of mice induced by high fat diet.

My role: PI

 

Project Number:

Agency: Hubei Provincial Academy for Preventive Medicine (complete)

Project Title: Synergistic effects of air pollution on vascular function in Obese mice.

My role: PI

 

Project Number: 81402668 (ongoing)

Agency: National Natural Science Foundation of China

Project Title: Investigation of the mechanism by which eating frequency and timing of feeding regulate body weight of Sprague-Dawley rats

My role: Co-PI

 

Project Number: 2014CFB422 (complete)

Agency: Natural Science Foundation of Hubei Province

Project Title: Effects of lifestyle intervention on Klotho methylation and endothelial function in Preeclampsia.

My role: Co-PI

 

Project Number: JX6B63 (complete)

Agency: Health and Family commission of Hubei Province

Project Title: Endothelial function modulated by Klotho in Preeclampsia development and pregnancy outcomes.

My role: Co-PI

 

Selected Peer-reviewed Publications:

1. Fan C, Wang Y, Wang J, Lei D, Sun Y, Lei S, Hu M, Tian Y, Li R, Wang S. Clinic significance of markedly decreased α-klotho in women with preeclampsia. Am J Transl Res. 2016 May 15;8(5):1998-2010.

2. Sun C, Liu Z, Li S, Yang C, Xue R, Xi Y, Wang L, Wang S, He Q, Huang J, Xie S, Jiang W, Li D. Down-Regulation of c-Met and Bc12 by microRNA-206, activates apoptosis, and inhibits, tumor cell proliferation, migration and colony formation. Oncotarget. 2015 Sep 22;6(28):25533-74.

3. Zhang J, Wang S, Huang W, Bennett DA, Dickson DW, Wang D, Wang R. Tissue Trans-glutaminase and Its Product Isopeptide Are Increased in Alzheimer's Disease and APPswe/PS1dE9 Double Transgenic Mice Brains. Molecular Neurobiology, 2015, Sept 15, p1-13.

4. Liu X, Huang T, Li L, Tang Y, Tian Y, Wang S, Fan C. CYP1B1 deficiency ameliorates obesity and glucose intolerance induced by high fat diet in adult C57BL/6J mice. Am J Transl Res. 2015 Apr 15;7(4):761-71.

5. Larsen MC, Bushkofsky JR, Gorman T, Adhami V, Mukhtar H, Wang S, Reeder SB, Sheibani N, Jefcoate CR. Cytochrome P450 1B1: An unexpected modulator of liver fatty acid homeostasis. Arch Biochem Biophys.2015

6. Yang J, Fan C, Pan L, Xie M, He Q, Li D, Wang S. C-reactive protein plays a marginal role in cognitive decline: a systematic review and meta-analysis. Int J Geriatr Psychiatry. 2015, Feb; 30 (2): 156-65.

7. Ji J, Wang SQ, Liu YJ, He QQ.(2013). Physical Activity and Lung Function Growth in a Cohort of Chinese School Children: A Prospective Study. PLoS One. 2013; 8(6): e66098.

8. Wu Z, Wang S. Role of kruppel-like transcription factors in adipogenesis. Dev Biol. 2013; 3(2):235-43.

9. Liu RM, Vayalil PK, Ballinger C, Dickinson DA, Huang WT, Wang S, Kavanagh TJ, Matthews QL, Postlethwait EM. Transforming growth factor β suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis model. Free Radic Biol Med. 2012; 53(3):554-63.

10. Wang PG,Gong J,Wang SQ, Talbott EO, Zhang B, He QQ. Relationship of body fat and cardiorespiratory fitness with cardiovascular risk in Chinese children. Plos One. 2011; 6 (11):e27896.

11. Westmark PR, Westmark CJ, Wang SQ, Levenson J, O’Riordan KJ, Burger C, and Malter JS. Pin1 regulates dendritic protein synthesis and synaptic plasticity. Sci Signal. 2010;3(112):ra18.

12. Wang, S., Wang R., Wang DS. Expression and functional profiling of NEP, IDE, and ECE in prospectively studied elderly and Alzheimer’s brain. J Neurochem. 2010; 5(1):47-57.