Department of Occupational and Environmental Health
Li Dejia (Professor)
Date:2015-12-30  Clicks:

Dejia Li

Post and Title:Professor, Doctoral supervisor, Chutian scholar, Vice director

Department:Department of preventive medicine;


Personal Profile

Dejia Li, Associate Editor of Journal of translational medicine,Lead Guest Editorof Journal Current Pharmaceutical Design for special issue “Towards microRNA-based therapeutics in lung cancer. After PhD graduated from College of Life Science, Wuhan University, Prof. Li was invited by Prof. Dongsheng Duan to the University of Missouri-columbia for postdoctoral research in 2006. During the time, he published 11 papers in Hum Mol Genet, J Cell Sci, J Pathol, Am J Pathol, J Clin Invest, Hum Gen Ther, PLoS ONE and so on. After returned from America in 2011, he continued the researches on Duchenne Muscular Dystrophy and the pathogenesis and began to study biological function of non coding RNA in lung cancer and published 23 papers in SCI journals such as The Journal of Biological Chemistry, Molecuar Therapy-Nucleic Acids, Oncotarget, Aging-US, Journal of Gastroenterology, Journal of Applied Physiology, Molecular Biosystems. In which 4 papers were selected as ESI 2017 high cited papers. Up to now, he published more than 63 articles, and 42 of them were indexed by SCI. And he was invited to review manuscript for SCI journals such as American Journal of Pathology, The Journal of Endocrinology & Metabolism, Cacner Letters, Molecular Cancer, International Journal of Cancer, Scientific Report, Oncotarget, Molecular Therapy-Nucleus Acids, Carcinogenesis, Aging-US and so on.

Research Interest:Lung cancer tumogenesis, Biological function of non coding RNA in cancer, RNA alternative splicing

Selected Publications as corresponding author in recent three years:

Selected Publications as corresponding author in recent three years:

1.Pan, JY*,Zhang, F8, Sun, CC*#, Li, SJ, Li, G, Gong, FY, He, J, Hua, RX, Hu, WD, Yuan, ZP, Wang, X, He, QQ and Li, DJ#. Mir-134:a human cancer suppressor? Mol Ther Nucleic Acids, 2017.6(1): doi:10.1016/j.omtn.2016.11.003. (IF 5.048)

2.Sun, C, Li, S, Yuan, Z,Li, D.MicroRNA-346 facilitates cell growth and metastasis, and suppresses cell apoptosis in human non-small cell lung cancer by regulation of XPC/ERK/Snail/E-cadherin pathway.Aging.2016, 8(10),1509-24.(IF 3.979)

3.Sun, CC, Li, SJ, Zhang, F, Zhang, Y, Zuo, Z, Xi, YY, Wang, L, andLi, DJ.The novel miR-9600 suppresses tumor progression and promotes paclitaxel sensitivity in non-small cell lung cancer (NSCLC) through altering STAT3 expression.Mol Ther Nucleic Acids, 2016.5(11):e387.(IF 5.048)

4.Sun, CC, Li, SJ, Li G, Hua, R, Zhou, XH,Li, DJ.Long intergenic non-coding RNA 00511 acts as an oncogene in non-small cell lung cancer by binding to EZH2 and suppressing p57.Mol Ther Nucleic Acids,2016. 5(11): e385.(IF 5.048)

5.Sun,C, Li, S, Zhang, F, Xi, Y, Wang, L, Fu, Z, Zhang, Y, Bi, Y, andLi, D.Long non-coding RNA NEAT1 promotes non-small cell lung cancer progression through regulation of miR-377-3p-E2F3 pathway.Oncotarget.2016, 7(32), 51784-51814.(IF 5.008)

6.Sun, C, Li, S,Li, D.Hsa-miR-134 suppresses non-small cell lung cancer (NSCLC) development through down-regulation of CCND1.Oncotarget.2016, 7(24), 35960-35978.(IF 5.008)

7.Yang C*,Sun C*, Liang X, Xie S, Huang J, andLi D.Integrative analysis of microRNA and mRNA expression profiles in non-small-cell lung cancer.Cancer Gene Therapy.2016, 23(4):90-97.(IF 2.532)

8.Sun, C,Li, S, Yang, C, Xi, Y, Wang, L, Zhang, F andLi D.MicroRNA-187-3p mitigates non-small cell lung cancer (NSCLC) development through down-regulation of BCL6.Biochem Biophys Res Commun:2016;471:82-88. (IF 2.371)

9.Sun, CC, Li, SJ, Zhang, F, Pan, JY, Wang, L, Yang, CL Xi, YY, Wang, L andLi DJ.Hsa-miR-329 exerts tumor suppressor function through down-regulation of MET in non-small cell lung cancer.Oncotarget, 7(16):21510-21526.(IF 5.008)

10.Sun, C, Huang, C, Li, S, Yang, C,Xi,Y,Wang, L and Li D.Hsa-miR-326 targets CCND1 and inhibits non-small cell lung cancer development.Oncotarget.2016, 7(7):8341-8359. (IF 5.008)

11.Sun C, Li S andLi D.Sulforaphane mitigates muscle fibrosis in mdx mice via Nrf2-mediated inhibition of TGF-beta/Smad signaling.J Appl Physiol(1985). 2016; 120:377-390. (IF 3.004)

12.Sun, Cheng-Cao, Li, Shu-Jun, Yang, Cui-Li, Xue, Rui-Lin, Xi, Yong-Yong, Wang, Liang, Zhao, Qian-Long,Li, De-Jia, Sulforaphane Attenuates Muscle Inflammation in Dystrophin-deficient mdx Mice via NF-E2-related Factor 2 (Nrf2)-mediated Inhibition of NF-kappaB Signaling Pathway.,Journal of Biological Chemistry, 2015.7.17, 290(29):17784-17795

13.Sun, Chengcao, Yang, Cuili,Xue, Ruilin, Li, Shujun, Zhang, Ting, Pan, Lei, Ma, Xuejiao, Wang, Liang,Li, Dejia, Sulforaphane alleviates muscular dystrophy in mdx mice by activation of Nrf2.,J Appl Physiol(1985), 2015.1.15, 118(2):224-237

14.Chengcao Sun, Ming Sang, Shujun Li, Xiaodong Sun, Cuili Yang, Yongyong Xi, Liang Wang, Feng Zhang, Yongyi Bi, Yunfeng Fu,Dejia Li, Hsa-miR-139-5p inhibits proliferation and causes apoptosis associated with down-regulation of c-Met,Oncotarget, 2015.11.25, 6(37):39756-39792

15.Huang, Chuan-Feng, Sun, Cheng-Chao, Zhao, Fang, Zhang, Ya-Dong,Li, De-Jia, miR-33a levels in hepatic and serum after chronic HBV-induced fibrosis.,Journal of Gastroenterology, 2015.4.01, 50(4):480-490

16.Chengcao Sun, Zhidong Liu, Shujun Li, Cuili Yang, Ruilin Xue, Yongyong Xi, Liang Wang, Suqing Wang, Qiqiang He, Jie Huang, Songping Xie, Wenyang Jiang,Dejia Li, Down-regulation of c-Met and Bcl2 by microRNA-206, activates apoptosis, and inhibits tumor cell proliferation, migration and colony formation,Oncotarget, 2015.9.22, 6(28):25533-25574

17.Huang, Junchao, Sun, Chengchao, Wang, Suqing, He, Qiqiang,Li, Dejia, microRNA miR-10b inhibition reduces cell proliferation and promotes apoptosis in non-small cell lung cancer (NSCLC) cells.,Mol Biosyst, 2015.7.01, 11(7):2051-2059

18.Wang, Liang, Xi, Yongyong, Sun, Chengcao, Zhang, Feng, Jiang, Heng, He, Qiqiang,Li, Dejia, CDK3 is a major target of miR-150 in cell proliferation and anti-cancer effect,Exp Mol Pathol,2017.1.17, 102(2):181-190

19.Xue, Ruilin, Yang, Cuili, Zhao, Fang,Li, Dejia, Prognostic significance of CDH13 hypermethylation and mRNA in NSCLC.,OncoTargets and Therapy, 2014.01.01, 7:1987-1996

20.Xi, Yongyong, Wang, Liang, Sun, Chengcao, Yang, Cuili, Zhang, Feng,Li, Dejia,The novel miR-9501 inhibits cell proliferation, migration and activates apoptosis in non-small cell lung cancer,Medical Oncology, 2016.11.01, 33(11)

21.Wang Liang, Xue Ruilin, Sun Chengcao, Yang Cuili, Xi Yongyong, Zhang Feng, He Qiqiang, Wang Suqing, Zhao Fang, Zhang Yadong,Li Dejia, SIRT1 regulates C2C12 myoblast cell proliferation by activating Wnt signaling pathway,Int J Clin Exp Pathol, 2016.3.15, 9(3):2857-2868

22.Cuili Yang, Lei Pan, Chengcao Sun, Yongyong Xi, Liang Wang,Dejia Li, Red Meat Consumption and the Risk of Stroke: A Dose–Response Meta-analysis of Prospective Cohort Studies,Journal of Stroke and Cerebrovascular Diseases, 2016.5.01, 25(5):1177-1186

23.Liang Wang, Ting Zhang, Yongyong Xi, Cuili Yang, Chengcao Sun,Dejia Li, Sirtuin 1 promotes the proliferation of C2C12 myoblast cells via the myostatin signaling pathway,Molecular Medicine Reports, 2016.5.27, 14:1309-1315